AT 13148
AT13148
CAS: 1056901-62-2
Molecular Formula: C17H16ClN3O
AT 13148 - Names and Identifiers
AT 13148 - Physico-chemical Properties
| Molecular Formula | C17H16ClN3O |
| Molar Mass | 313.78 |
| Density | 1.328±0.06 g/cm3(Predicted) |
| Boling Point | 595.9±50.0 °C(Predicted) |
| Solubility | 10 mM in DMSO |
| pKa | 10.92±0.50(Predicted) |
| Storage Condition | -20℃ |
| In vitro study | AT13148, as a multi-AGC kinase inhibitor, potently inhibit with GI50 values of 1.5 to 3.8 μm cross a selected panel of cancer cell lines with deregulation of PI3K-AKT-mTOR or RAS-RAF pathways. In PTEN-deficient MES-SA cells, AT13148 also inhibit AKT and p70S6K signaling. AT13148, as a multiplex AGC kinase inhibitor, effectively inhibits cancer cell proliferation with GI50 values of 1.5 to 3.8 μm for a selected group of PI3K-AKT-mTOR or RAS-RAF pathway aberrant cancer cell lines. In PTEN-deficient MES-SA cells, AT13148 also inhibited AKT and p70S6K signaling. |
| In vivo study | AT13148 (50 mg/kg p.o.) markedly inhibits the activity of both AKT and p70S6K AGC kinases, and subsequently exhibits marked antitumor effects in human tumor xenografts. in human tumor xenografts, AT13148 (50 mg/kg p.o.) the activity of AKT and p70S6K AGC kinases were significantly inhibited and subsequently exhibited a significant anti-tumor effect. |
AT 13148 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.187 ml | 15.935 ml | 31.869 ml |
| 5 mM | 0.637 ml | 3.187 ml | 6.374 ml |
| 10 mM | 0.319 ml | 1.593 ml | 3.187 ml |
| 5 mM | 0.064 ml | 0.319 ml | 0.637 ml |
Last Update：2024-01-02 23:10:35
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